INVESTIGATION OF ANTHOCYANIN CONTENT AND CYTOTOXIC ACTIVITY IN DIFFERENT EXTRACTS OF FRUIT PEALS OF SOLANUM MELONGENA L.

نویسندگانمریم اخباری,محمدرضا حائری,معصومه بابایی
همایشچهارمین کنفرانس ملی گیاهان دارویی
تاریخ برگزاری همایش۲۰۱۵-۵-۱۲
محل برگزاری همایشتهران
سطح همایشملی
چکیده مقالهAnthocyanins are an important group of secondary metabolites. They are well known because of having high antioxidant activities, inhibition of mutagenic effects and cancers and also anti-aging properties. On the other hands, these compounds are also very usable natural pigments in food and drug industries. The purpose of this research is to evaluate anthocyanin content and study of cytotoxic activity for fruit peel of Solanummelongena, harvested in Kashan, and comparing the effect of extraction solvent on them. In this study, anthocyanin contents of fruit peel of Solanum melongena with the common name 'egg plant' was evaluated via UV-Vis absorbtion measuring. To select the best extraction solvent, water, methanol and ethanol were used to extract these valuable compounds.The three extracts also were investigated to evaluate cytotoxic activity for screening anticancer effects via brine shrimp lethality assay. Amounts of extracted anthocyanins using water, methanol and ethanol, were 412, 354, 293 mg/100g and cytotoxic activities (LC50) were 750, 525 and 1000 μg/mL for each extract respectively.