Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran

نویسندگانسعید توکلی-محمدرضا دلنوازی-رضا حاجی آقایی-سعیده جعفری ندوشن-فرهناز خلیقی سیگارودی-مریم اخباری-عباس حاجی آخوندی-نرگس یاسا
نشریهNatural product research
تاریخ انتشار۲۰۱۷-۹-۰۱
نمایه نشریهISI ,ISC ,PubMed
چکیده مقالهPhytochemical analysis of the Ferulago trifda Boiss. from Apiaceae family led to the isolation and identifcation of suberosin (1), isoimperatorin (2), prantschimgin (3), oxypeucedanin (4), oxypeucedanin methanolate (5), suberenol (6), 6-hydroxymethylherniarin (7), oxypeucedanin hydrate (8), ulopterol (9), bergapten (10), xanthotoxin (11), imperatorin (12) and grandivittin (13) from chloroform extracts of the roots (1–9) and fruits (1, 2, 8, 10–13) of this species. Oxypeucedanin methanolate and suberenol demonstrated a potent antioxidant power with 268.2 ± 5.4 and 251.2 ± 6.2 mmol FSE/100 g, respectively, compared by BHT (267.2 ± 4.2 mmol FSE/100 g) in FRAP method. The potent antibacterial effects were found for oxypeucedanin methanolate on S. epidermidis (IZ; 26 mm, MIC; 250 μg mL−1) an oxypeucedanin hydrate on K. pneumoniae (IZ: 21 mm, MIC: 250 μg mL−1). Moreover, suberosin showed higher preferential toxicity against MDA-MB-23 cells (IC 50: 0.21 mM, SI: 5.0), in comparison with tamoxifen (IC50: 0.012 mM, SI: 2.45) in MTT assay.