A green and efficient synthesis of 2, 3, 4, 5- tetra-substituted imidazoles using Nb2O5-Fe3O4 core shell nano catalyst under thermal electrical grinding

Abstract

The synthesis of imidazole derivatives has been the subject of extensive research, with various synthetic strategies developed over the years. One particularly efficient approach involves a multicomponent reaction that combines 1,2-diketones, aldehydes and their derivatives, ammonium acetate, and aromatic amines in the presence of a suitable catalyst.