Rapid four-component synthesis of dihydropyrano[2,3-c]pyrazoles using nano-eggshell/Ti(IV) as a highly compatible natural based catalyst

AuthorsArefeh Dehghani Tafti, Bi Bi Fatemeh Mirjalili, Abdolhamid Bamoniri, Naeimeh Salehi
JournalBMC Chemistry
IFثبت نشده
Paper TypeFull Paper
Published At2021-01-25
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexSCOPUS ,JCR

Abstract

Nano-eggshell/Ti(IV) as a novel naturally based catalyst was prepared, characterized and applied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. The characterization of nano-eggshell/Ti(IV) was performed using Fourier Transform Infrared spectroscopy, X-ray Diffraction, Field Emission Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, and Thermo Gravimetric Analysis. Dihydropyrano[2,3-c]pyrazoles were synthesized in the pres-ence of nano-eggshell/Ti(IV) via a four component reaction of aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate at room temperature under solvent free conditions. The principal affairs of this procedure are mild condition, short reaction times, easy work-up, high yields, reusability of the catalyst and the absence of toxic organic solvents.

tags: Dihydropyrano[2,3-c]pyrazole, Nano-eggshell/Ti(IV), Multicomponent reactions, Eggshell, Titanium tetrachloride, Natural catalyst