Synthesis of N,N´-Alkylidenebisamides in the Presence of Fe3 O4 @ Nano-Cellulose/B(III) as a Natural Based Super Paramagnetic Nanocatalyst

Abstract

Fe3 O4 @nano-cellulose/B(III) was synthesized as natural based super paramagnetic nano-catalyst and characterized by FT-IR, VSM, XRD, XRF, BET, FESEM, TEM, TGA and EDS(EDX) techniques. Natural base of this nano magnetic catalysis is nano-cellulose which prepared from hydrolysis of glucoside linkage of cotton cellulose. Bis-amides can be easily transformed into other functionalities and also, used for the synthesis of pharmacological materials such as peptidomimetic compounds. In this work, Fe3O4@nano-cellulose/B(III) was successfully applied to the synthesis of N,N’-alkylidenebisamides derivatives via one-pot threecomponent condensation reaction of various aldehydes and amides. N,N’- alkylidenebisamides have been prepared under solvent-free conditions at 70 °C. The super paramagnetic catalyst was removed from reaction mixture by an external magnet without any filtration. The structure of obtained products were investigated by FTIR (ATR), 1 H-NMR and 13C NMR. All of the reactions proceeded in high yields and in short reaction times. This method offers several advantages including recyclability of catalyst, easy work-up, excellent yields and short reaction time.