Synthesis of bis-spiro piperidines using nano galumina supported Sb(V) under ultrasonic irradiation at room temperature conditions

Abstract

Group VA metalloid ion Lewis acids, Sb(V) was identified as a highly potent catalyst for the one-pot threecomponent synthesis of bis-spiro piperidine derivatives. The reaction was performed using amines, formaldehyde, and dimedone under ultrasonic irradiation at room temperature. The strong acidic property of the nano g-alumina supported antimony(V) chloride plays a key role in accelerating the rate of the reaction and initiates the reaction smoothly. The h