NANO-SILICA PHOSPHORIC ACID: AN EFFICIENT CATALYST FOR ONE-POT SYNTHESIS OF 3, 4-DIHYDROPYRIMIDIN-2 (1 H) -ONES (THIONES) UNDER SOLVENT-FREE OR SONICATION CONDITIONS

Authorsعبد الحمید بامنیری,بی بی فاطمه میرجلیلی,صدیقه ناظمیان
JournalIRANIAN JOURNAL OF CATALYSIS
Page number17
Volume number2
IFثبت نشده
Paper TypeFull Paper
Published At2012-05-30
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexSCOPUS ,ISC

Abstract

Two simple protocols for the synthesis of three-component condensation reaction of an aldehyde, β-ketoester and urea or thiourea to obtain the 3, 4-dihydropyrimidin-2(1H)-ones (thiones) using nano silica phosphoric acid are reported. Short reaction times, high yields, reusability of catalyst and easy workup are some advantages of these protocols.

tags: Biginelli reaction, 3,4-Dihydropyrimidin-2(1H)-ones, 3,4-Dihydropyrimidin-2(1H)-thiones, Heterogeneous catalyst, Multi-component reactions, Nano silica phosphoric acid, Sonication condition.