Nano-Fe3O4@SiO2/SnCl4 Promoted Synthesis of Indenopyrido[2,3-d] Pyrimidine Derivatives in Water

Abstract

Pyrido[2,3-d]pyrimidine derivatives show variable biological activities such as anticancer, antitumor, antiviral, antihistaminic, anti-inflammatory and antibacterial. In this work, an efficient and environment friendly method for one-pot synthesis of indenopyrido[2,3-d]pyrimidine derivatives was developed in the presence of nano-Fe3O4@SiO2/SnCl4 nanoparticles in water. Indenopyrido[2,3-d]pyrimidines were synthesized via three-component couplings of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, aldehydes and 1,3-indanedione under heating or ultrasound irradiation conditions in water. The structure of the obtained products was approved by FT-IR, 1H NMR and 13C NMR techniques. The mild reaction conditions, green and cost-effective catalyst, excellent yields, and easy work-up procedures, which avoid the use of large volumes of hazardous organic solvents, make it a useful protocol.