Synthesis of novel phenylalaninol-based benzamides as dopamine receptor ligands

چکیده مقاله

we began this study by preparing L-phenylalaninol in one step from the corresponding amino acids namely L-phenylalanine, which were reduced under standard conditions using NaBH4-I2 in dry THF. The conversions of phenylalaninol into the corresponding N-alkyl, allyl or propargyl amino alcohol derivatives were carried out then coupled with N-tert-butyloxycarbonyl-2-bromo-l-aminoethane. Finally coupled with 2,6- dimethoxy benzoyl chloride for synthesis of new phenylalaninol-based benzamides.