Investigation on the Corrosion Resistance and Release of Gentamicin Drug from Titanium Implant Reinforced by Polyethylene Glycol / Polyvinyl Alcohol Based Polymer Composite Coating

Abstract

The main reasons for the failure of titanium implants are insignificant infection with cataracts and ossoeintegration. In this paper, the production of titanium dioxide nanotubes on a titanium substrate by electrochemical anodization method is a suitable substrate for nanocomposite coatings. Polyethylene glycol (PEG) polymer coating on the surface of titanium dioxide nanotubes increases biocompatibility and controls long-term drug release kinetics. Polyvinyl alcohol (PVA) polymer coating is a biodegradable polymer that controls drug release. Polymer coatings on the surface of titanium dioxide nanotubes also increase the corrosion resistance of titanium dioxide nanotubes. Using gentamicin (gen) as an antibiotic increased the antimicrobial susceptibility of the implant. Electrochemical results show that the simultaneous coating of two polymers of polyethylene glycol and polyvinyl alcohol increased the corrosion resistance of the implant, and its corrosion current (1.6843 × 10 -6A/cm2 ) decreased. Microbial results showed that the sample of titanium dioxide nanotube coated with gentamicin had the highest antimicrobial properties and the lowest optical density (0.5). Because when titanium dioxide nanotubes are co-layered with polymer in addition to gentamicin, it causes the drug to show less antimicrobial properties. The cytotoxicity results show that the sample of titanium dioxide nanotubes coated with polyethylene glycol and the drug has the highest cell viability percentage (99.5%) because gentamicin has high antimicrobial properties for the cell and polyethylene glycol polymer has low antimicrobial properties for cells.