Synthesis of Novel bis-spirooxindoles Catalyzed by Magnetic Cobalt Ferrite Encapsulated MCM-41@MgO as a Solid Base

Abstract

Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile, and various derivatives of cyclohexanones. Background: A facile one-pot and four-component reaction was investigated for the synthesis of novel bisspirooxindoles from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence of magnetic CoFe2O4@MCM-41@MgO NPS catalyst under mild conditions. Materials and Methods: Firstly, the magnetic CoFe2O4@MCM-41@MgO was prepared in three steps. Afterwards, the CoFe2O4@MCM-41@MgO was used as a base catalyst for the one-pot synthesis of bisspirooxindoles.