Synthesis of Novel bis-Spirooxindoles Using Triethylamine as a Homogeneous Base Catalyst under Mild Conditions

Authorsسمیه محمدی,حسین نعیمی
JournalORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
Page number25
Volume number53
IF1.628
Paper TypeFull Paper
Published At2021-05-10
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexSCOPUS ,JCR

Abstract

We now report our investigation into the preparation of novel bis-spirooxindoles (2) under mild conditions (Scheme 1). As starting materials, we used spirooxindoles (1), themselves readily prepared from malononitrile, isatin derivatives, and cyclohexanones. In a procedure of particular interest for its convenience, the bis-spirooxindoles were generated in methanol with triethylamine as a homogeneous base catalyst at room temperature (see Experimental section).

tags: bis-Spirooxindoles, Synthesis, Catalyst, Triethylamine