Synthesis of 1H-isochromenes, 4H-chromenes, and orthoaminocarbonitrile tetrahydronaphthalenes from the same reactants by using metal-free catalyst

Authorsحسین نعیمی,سمیه محمدی
JournalJ Heterocycl Chem
Page number1
Volume number20
IF1.484
Paper TypeFull Paper
Published At2019-12-20
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexJCR

Abstract

A facile and rapid multicomponent synthesis of pharmaceutically diverse 1Hisochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes has been developed from benzaldehyde, malononitrile, and cyclohexanone. Three different methods from the same reactants, solvent, temperature, and catalyst lead to three products with excellent yields. All the reactions were followed with the Michael addition and cyclization. In this study, morpholine was used as an active metal-free base catalyst that increases the yields of products and decreases the time of reactions.

tags: catalyst, multicomponent, 1H-isochromenes, 4H-chromenes