Facile one-pot four component synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines catalyzed by CuFe2O4 magnetic nanoparticles in water

Abstract

A simple, efficient and green method for the synthesis of pyrido[2,3-d:6,5-d′]dipyrimidine derivatives via one-pot four-component reaction of aromatic aldehyde, 2-thiobarbituric acid, ammonium acetate in the presence of catalytic amount of a magnetically heterogeneous catalyst has been developed. This protocol includes some important advantages such as; high to excellent product yields, high atom economy, usage of water as a green reaction medium, reusability of catalyst, and simple work-up procedure.