Metal–free GO-SiPr-SO3H Nanosheets Catalyzed Ultrasound Promoted One–pot Synthesis of Star-Shape Phenolic Compounds in Water and Study of Their In–vitro Antimicrobial Activities

Abstract

An efficient and pseudo-three-component approach to obtain star-shape phenolic compounds using 2,4-dialkylphenol and aromatic, aliphatic, bis-aldehyde and heteroaldehyde was reported using GO-SiPr-SO3H in water under ultrasound irradiation. The ultrasound irradiation had positive effect on catalytic activity of the GO-SiPr-SO3H catalyst. The desired products were achieved in good to excellent yields at short reaction times. Also, the structure of star-shape phenolic compounds was approved using density functional theory (DFT) calculation. In addition, in vitro antimicrobial activity of the stnthetic compounds was evaluated.