An Efficient One-Pot Multicomponent Synthesis of 4-Aza-Podophyllotoxin Derivatives in Ionic Liquid

Authorsحسین نعیمی,زهرا رشید,امیرحسن زرنانی,رامین قهرمان زاده
JournalE-J CHEM
Page number1
Volume number2013
Paper TypeFull Paper
Published At2013-10-11
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexISI ,SCOPUS

Abstract

A simple, green, and efficient procedure for the synthesis of 4-aza-podophyllotoxin derivatives by using a one-pot three-component reaction of benzaldehydes, 1,3-cyclohexanediones, and anilinolactones in the presence of catalytic amount of alum in 1-butyl-3-methylimidazolium triflate as green media is described. This reaction proceeded under mild conditions with the use of an inexpensive and readily available catalyst, high to excellent yields, and simple workup procedure.

tags: One-Pot, Multicomponent, 4-Aza-Podophyllotoxin, Ionic Liquid