| نویسندگان | حدیث بشیری-سیدحسین رسا-حامد مرادمندجلالی |
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| نشریه | Progress in Reaction Kinetics and Mechanism |
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| تاریخ انتشار | 2014-9-01 |
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| نمایه نشریه | ISI ,SCOPUS |
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چکیده مقاله
Reactive oxygen species (ROS) are reactive molecules which are produced
normally by metabolic reactions. 2,7-Dichlorofluorescein diacetate (DCHFDA)
assay is used to determine intracellular levels of ROS in cancer cells. In
the present study, the mechanism and kinetic parameters of this determination
are obtained by kinetic Monte Carlo simulation. The values of the rate constants
for the suggested mechanism were obtained by simulation. Then, the effect of
DCHF‑DA concentration on the rate of reaction was studied. According to the
results, the product concentration should increase on increasing the DCHF‑DA
concentration. In addition, the effect of ROS concentration on the rate of
reaction was determined.
