Statistical analysis of insect anticancer peptides

Abstract

Introduction: Compared to conventional cancer treatments such as radiotherapy or chemotherapy, a way to protect healthy cells can be suggested like biological treatmentsthe such as use of proteins, peptides, etc that have been studied against cancer. Insect resistance to pathogens has certainly contributed to their proliferation and diversity and have a very strong innate immune system to annihilate aggressive pathogens, most insect antimicrobial peptides are small and show activity against bacteria or fungi as well as some parasites and viruses. Description: Based on data from The Antimicrobial Peptide Database, we have collected about 300 insecticidal antimicrobial peptides that have various activities including antifungal, antibacterial, antiviral, anti-inflammatory, antioxidant, etc. There were also 21 peptides with anticancer activity Now due to the cancer dilemma, we examined those peptides that had anticancer properties. We investigated these peptides for their hydrophobicity, chain length, and the type of amino acids used and their characteristics. Discussion and conclusion: After statistical comparison, about 3% of peptides had a negative charge and 27% had a positive charge, about 51.5% of the peptides were nonpolar and aliphatic which is a large percentage, and 18% were polar uncharge. The average length of polypeptide chains was 23, net charge 4.5 and hydrophobicity 47.5%, which is a significant number. Comparison of these numbers and using their results could be useful in basic studies on these peptides and provide a basis for designing new experiments on them