| Authors | فاطمه پارسا,مسلم ستوده خواه,سید محمد اطیابی |
|---|
| Journal | Inorganic Chemistry communucation |
|---|
| Page number | 111056 |
|---|
| Volume number | 115 |
|---|
| IF | 3.8 |
|---|
| Paper Type | Full Paper |
|---|
| Published At | 2023-07-10 |
|---|
| Journal Grade | Scientific - research |
|---|
| Journal Type | Electronic |
|---|
| Journal Country | Iran, Islamic Republic Of |
|---|
| Journal Index | SCOPUS ,JCR |
|---|
Abstract
In this work, a magnetic and porous nanocomposite was prepared via synthesis of MIL-100(Fe) in the presence of
magnetite nanoparticles that are well supported by silica (Fe3O4@SiO2). This nanocomposite due to its magnetic
properties was used as an efficient nanocarrier for targeted ciprofloxacin (CIP) drug delivery. The loading and
release behavior of CIP was evaluated in environments with different pH. The highest drug loading efficiency
(DLE) was observed in AB (acetate buffer, pH:5.0) solutions and deionized water about 97.5% and 73%,
respectively within 24 h. While during this period, the drug loading content (DLC) was estimated as 16.3% and
12.7%. The adsorption behavior of CIP was evaluated using Langmuir, Freundlich, Dubinin–Radushkevich
(D–R), Temkin and Redlich-Peterson equations. The results revealed that the experimental data were fitted by
Freundlich isotherm model. This isotherm shows that the drug is adsorbed multilayered on the nanocomposite
active sites. Also the adsorption process was completed by following pseudo-second-order and intra-particle
adsorption kinetics in 48 and 30 h under physiological and acidic conditions, respectively. From the analysis
of BET and EDX-map results, it was revealed that the drug is both loaded into the pores of the nanocomposite and
is uniformly absorbed on the surface of the nanocomposite. The kinetics of drug release was also investigated.
Among the perused release kinetic mechanisms, the Korsmeier-Peppas model is inconsistent with the results well.
Antibiogram analysis was performed to determine the zone of inhibition of Pseudomonas aeruginosa and Staphylococcus
epidermidis.
The
drug-loaded
nanocarrier
was
evaluated
for
in
vitro
cytotoxicity
using
the
MTT
assay
at
different
times
and
concentrations
in
MCF-7
cancer
and
L929
normal
cell
lines.
The
results
showed
significant
biotoxicity
of
the
drug-loaded
nanocarrier
against
cancer
cell
lines
and
less
toxicity
on
normal
cells.
Due
to
the
magnetic
property
of
the
nanocarrier,
it
has
potential
as
an
engaged
nanocarrier
for
future
in
vivo
targeted
drug
delivery
studies.
