Improvement of interaction between PVA and chitosan via magnetitenanoparticles for drug delivery application

چکیده مقاله

tMagnetite nanoparticles were synthesized by coprecipitation under ultrasonication followed by coatingwith chitosan. Polyvinyl alcohol (PVA) is then combined with the chitosan that coated the magnetitenanoparticles. The combination occurs by hydrogen binding and ionic cross-linking of the amino andhydroxyl groups of chitosan and PVA respectively. The magnetite nanoparticles have an average size of10.62 nm that was confirmed by TEM. The VSM measurements showed that nanoparticles were super-paramagnetic. The coatings on the core nanoparticles were estimated by AAS and the attachments ofcoating to the nanoparticles were confirmed by FT-IR analysis. Physicochemical properties of nanopar-ticles were measured by DLS and zeta potential. Naked magnetite, chitosan and PVA coating have zetapotential of +36.4, +48.1 and −12.5 mV respectively. The unspecific adsorption and interaction betweennanoparticles and bovine serum albumin (BSA) were investigated systematically by UV–vis spectroscopymethod. The nanoparticles that were modified by PVA present low protein adsorption, which makes thema practical choice for preventing opsonization in clinical application and drug delivery.