| Authors | G Sodeifian-CM Hsieh- R Derakhsheshpour-YM Chen- F Razmimanesh |
|---|---|
| Journal | Arabian Journal of Chemistry |
| Presented by | بله |
| Volume number | 15 |
| Paper Type | Original Research |
| Published At | 2022-4-1 |
| Journal Grade | ISI |
| Journal Type | Electronic |
| Journal Country | Netherlands |
Abstract
Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 × 10-5 to 5.56 × 10-5. To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated.