Solubility measurement of Ceftriaxone sodium in SC-CO2 and thermodynamic modeling using PR-KM EoS and vdW mixing rules with semi-empirical models

Abstract

The complete investigation of the solubility of Ceftriaxone sodium drug has not yet been conducted. This communication investigates the solubility of Ceftriaxone sodium drug in supercritical CO2 (SC-CO2) for the first time. The drug solubility measurements were performed using utilizing UV-vis analysis under different operation conditions (at P (bar) = 120-270 and T (K) = 308-338). The results demonstrated that the solubility of Ceftriaxone sodium ranged from 0.90 × 10-6 to 8.01 × 10-6. The mole fraction solubility of Ceftriaxone sodium increases proportionally with an increase in the pressure, while maintaining a constant temperature. However, a crossover was noted. The solubility behavior of Ceftriaxone sodium drug in SC-CO2 was modeled by Peng-Robinson equation of state (PR EoS) with Kwak-Mansoori and van der Waals mixing rules and seven semi-empirical correlations (Bian et al., Kumar-Johnston, Chrastil, Garlapati-Madras, Bartle et al., Sung-Shim and Sodeifian et al.,). The vaporization, total and solvation enthalpies of the Ceftriaxone sodium/SC-carbon dioxide system were obtained by KJ, Chrastil, and Bartle et al. correlations. The evaluation of two methods was performed by absolute average relative deviation (AARD%). Both models exhibited a satisfactory level of agreement with the experimental data. Finally, PR/KM EoS and the Chrastil models, with AARD% values of 8.70% and 8.10% respectively, showed superior precision in accurately fitting the solubility data.