Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini-Review

چکیده مقاله

Supercritical carbon dioxide (SC-CO₂) is CO₂ that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC-CO₂ is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi-empirical, and intelligence models to establish suitable correlations. SC-CO₂ is one of the most important materials used in SCFs to study solubility. Another application of SC-CO₂ is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC-CO₂. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC-CO₂ in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

 

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