Studing the antimicrobial activity of methylated anthraquinone derivatives in comparison with doxorubicin

چکیده مقاله

Anthraquinones are a class of naturally occurring phenolic compounds that most of these substances came from plants and fungi [1]. Anthraquinone compounds are structurally similar to anthracycline antibiotics such as doxorubicin. In this study two methylated anthraquinone such as 1, 4-dimethylanthraquinone and 2-methylanthraquinone were synthesized and evaluated for antimicrobial activity against a set of 12 microorganisms and compared with doxorubicin, in vitro. Following microbial strains were provided and used in this research: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Shigella dysenteriae, Proteus vulgaris and Salmonella paratyphi-A serotype as example of Gram negative bacteria, Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis as examples of gram positive bacteria, Candida albicans, Aspergillus niger and Aspergillus brasiliensis as examples of fungal straines. Agar diffusion technique was used for the determination of preliminary antibacterial and antifungal activities [2]. Bacterial strains sensitive to the compounds in agar diffusion assay were studied for their minimal inhibition concentration (MIC) values using micro-well dilution assay method [3]. Our results indicated that doxorubicin was more active against bacteria than anthraquinone derivatives. 2-methylanthraquinone was active against Staphylococcus aureus and Staphylococcus epidermidis and 1, 4-dimethyanthraquinone was only active against Staphylococcus epidermidis. 1, 4-dimethyanthraquinone and 2-methylanthraquinone had no antifungal activities.