Determination of acetaminophen using nanoporous gold film electrode modified with titanium and chitosan

Abstract

Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical behaviour of acetaminophen on nanoporous gold film electrode modified with titanium and chitosan (CS-TiNPGF) electrode. The experimental results showed that acetaminophen exhibited a remarkable oxidation peak at 0.6V in pH7. CS-TiNPGF exhibited on excellent performance toward electrochemical oxidation of acetaminophen showing a significant decrease in the anodic over potential a high sensitivity and a low detection limit 1×10-8 mol/L for acetaminophen. The results indicated that the differential pulse response of acetaminophen was linear with its concertation in the range of 6×10-8 to 5×10-5 mol/L with a linear coefficient of 0.9891 and in the range of 6×10-5 to 7×10-4 mol/L with a linear coefficient of 0.9940. Furthermore, this electrode demonstrated good stability, repeatability, rapid response, and selectivity remarkably.