Highly sensitive carbon paste modified with Cu-MOF/ ionic liquid for determination of patent blue V

Abstract

As one of the third generation of cephalosporin category, cefixime has a considerable activity towards both gram-positive and gram-negative bacteria and its analysis is of interest. Based on the synthesized reduced graphene oxide/CoFe2O4/ionic liquid (IL) (1-Ethyl-3-Methylimidazolium) (IL/CoFe2O4/rGO) nanocomposite, a modified carbon paste electrode (CPE) is selected as a sensor for determining cefixime. The structure and ability of nanostructures are investigated by various techniques containing scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CHA). The suggested sensor is successfully used for the simultaneous determination of cefixime, mefenamic acid, and acetaminophen. Under optimized settings, the oxidation peak current presented linear dependence with the concentration of the drug in the range from 0.03-900 μM for DPV, and the value of detection limit of cefixime is calculated 0.025 μM. The values of electro-transfer coefficient (α) and diffusion coefficient (D) are achieved 0.9 and 1.17×10−6 cm2 s−1. The electro-oxidation of cefixime occurs at an approximate potential of 0.85 V with an irreversible oxidation peak. The proposed modified electrode shows high performance for the analysis of cefixime, mefenamic acid, and acetaminophen in pharmaceuticals and biological samples with good results.