Introducing of Li2FeMn3O8 /C–C3N4 /IL nanocomposite for electrochemical determination of pantoprazole sodium in real samples

Abstract

A new electrochemical sensor based on Li2FeMn3O8/C–C3N4 (LFMO/CCN)/1-ethyl-3-methylimidazolium chloride modified carbon paste electrode (CPE) has been constructed to measure pantoprazole sodium (PNZS). The electrochemical impedance spectroscopy (EIS) method was employed to evaluate the electrode charge-transfer resistances. Moreover, the differential pulse voltammetry method was used to detect PNZS in phosphate buffer solution (PBS) at pH 7.0. The detection limit of 80.0 × 10−9 M and 10.9 × 10−7 M was obtained under optimal conditions in the linear concentration range of PNZS 0.09–100 μM and 100–900 μM. Chronoampermetry technique was utilized to determine the diffusion coefficient (D) of PNZS on the modified electrode surface. The CCN/LFMO/IL/CPE was successfully used to determine PNZS in various drug formulations such as tablets and vials. Finally, simultaneous determination of PNZS and acetaminophen was accomplished with no interference based on the proposed sensor.