A nanoporous gold film sensor modified with polypyrrole/CuO nanocomposite for electrochemical determination of piroxicam and tramadole

Abstract

In this paper, an electrochemical sensor was developed to determine piroxicam (PX) and tramadole (Tr) based on their enhanced electrochemical responses at the surface of the polypyrrole/CuO nanocomposite-modified nanoporous gold film (NPGF) electrode. The experimental results showed that PX provide an oxidation peak at 0.65 V in pH =8.0. The DPV results were linearly affiliated on PX concentration within the two closed windows (C1PX =0.05–30.0 μM, correlation coefficient of 0.9905, and C2PX =50.0–300.0 μM, correlation coefficient of 0.9927). From voltammetric curves, the detection limit (LOD =3Sb/m) for PX at a surface of PPY- CuO-NPGF electrode was appeared to be 0.01 μM. Furthermore, the ability of PPY-CuO-NPGF electrode for simultaneous measurement of PX and Tr was investigated. The suggested sensor shows a long-time stability, good repeatability, and rapid response in the mixture media of PX and Tr.