Application of the C–C3N4/Li2CoMn3O8//IL nanocomposite for design a sensitive electrochemical sensor inorder to detection of cetirizine, acetaminophen and phenylephrine in biological and pharmaceuticals samples

Abstract

Due to the side effects of cetirizine overdose and the need to monitor its concentration in the human body, in this work, an electrochemical sensor has been prepared by utilizing a carbon paste electrode modified with Li2CoMn3O8/CC3N4 nanocomposite and ethyl-3-methyl-imidazolium chloride ionic liquid ([EMIM][Cl]) to determine cetirizine in the human blood serum sample and urine as well as drug samples. Li2CoMn3O8/CC3N4 nanocomposite was characterized by Fourier transform infrared (FT-IR), field emission scanning electron microscope (FESEM), and X-ray diffraction (XRD) analysis. The investigation of the influence of each modifier component showed that the existence of all components in modification has a synergistic effect. Li2CoMn3O8/ CC3N4/IL nanocomposite has a larger surface area relative to the components alone, thus providing a more fine- grained media to facilitate electron transfer during the reaction between analyte and electrode. Determination of cetirizine was performed in phosphate buffer solution with pH 7.0 and detection limits obtained in the concentration ranges of 0.03–0.9 and 3–300 μM was 11.8 ×10 9 M. The diffusion coefficient (D =9.2 ×10 6 cm 2 s 1 ) of cetirizine at the surface of the modified electrode was determined by chronoamperometry. Finally, simultaneous detection of cetirizine, phenylephrine and acetaminophen was performed using the suggested sensor without any interference.