Application of Ni,Ti-Organic Framework-Based Electrochemical Sensor for Determination of Metronidazole and Oxazepam in Real Sample

Abstract

Treatment of bacterial, protozoal, and anaerobic illnesses such trichomonosis and vaginosis with metronidazole (MTZ) is commonplace. Therefore, a straightforward method is presented in this research for creating a metal–organic framework (MOF)-based electrochemical sensor. Direct microwave synthesis was used to create a MOF based on a combination of nickel and titanium. The glassy carbon electrode (GCE) surface was modified applying this binary mixed-MOF. To electrochemically monitor MTZ in plasma samples, the GCE was modified. Under optimum circumstances, a linear limit of 0.1–200 µM was produced using a DPV detection technique with a detection limit of 30 nM. The technique repeats within 6.2 percent from one electrode to another and from one electrode to itself (n = 5). A good relative recovery percentage (> 95%) and satisfactory precision demonstrated the electrode’s plasma sample performance. It was also possible to detect both MTZ and oxazepam (OX) using the same sensor. Under optimum circumstances, the lowest detectable concentrations of MTZ and OX in the 0.1–12 µM range were 0.03 µM and 0.02 µM, respectively.