| Authors | شیوا شفیعی,مهدی شبانی نوش آبادی |
|---|
| Journal | RES CHEM INTERMEDIAT |
|---|
| Page number | 5181 |
|---|
| Volume number | 44 |
|---|
| IF | 1.674 |
|---|
| Paper Type | Full Paper |
|---|
| Published At | 2018-04-11 |
|---|
| Journal Grade | Scientific - research |
|---|
| Journal Type | Electronic |
|---|
| Journal Country | Iran, Islamic Republic Of |
|---|
| Journal Index | ISI ,SCOPUS |
|---|
Abstract
Raloxifene is an important estrogen receptor modulator with many side
effects, and determination of this drug is very important in biological samples. The
present research describes a ZnO decorated graphene nanosheet (ZnO/GrNS)/ionic
liquid based electrochemical sensor for the measurement of raloxifene. The ZnO/
GrNS were synthesized via direct chemical precipitation process and characterized
using the SEM-EDAX technique. Due to excellent conductivity of ZnO/GrNS and
ionic liquid, the suggested electrochemical sensor exhibited improved electrochemical response for raloxifene. After optimization of electrochemical conditions
and at the best state, the fabricated electrode displayed two linear dynamic ranges
(1.0 910
-10
–5.0910
-6
and 1.0910
-6
–5.0910
-4
M) with a detection limit
(DL) of 0.07 nM. Quantification analysis of raloxifene was successfully evaluated
using the suggested sensor in pharmaceutical samples.
