Fabrication of an Electroanalytical Sensor for Determination of Deoxyepinephrine in the Presence of Uric Acid Using CuFe2O4 Nanoparticle/Ionic Liquid Amplified Sensor

Abstract

Deoxyepinephrine (DXEP) is a catecholamine derivative with pharmaceutical activity to raise blood pressure. Therefore, the control of DXEP in biological samples is very important for human health. The proposed research introduces a fast electro-analytical strategy based on CuFe2O4/ionic liquid (1-Hexyl-3-methylimidazolium Bromide (1H3MBr)) nanocomposite modified pate electrode (CuFe2O4/1H3MBr/PE) for voltammetric determination of deoxyepinephrine. For this goal, the CuFe2O4 as conductive mediator was synthesized using facile sonochemical method and characterized by XRD and FESEM methods. The CuFe2O4/1H3MBr/PE exhibited good performance for determination of DXEP in the presence of uric acid (UA) with separated potential ∼170 mV. The CuFe2O4/1H3MBr/PEwas showed linearly proportional to DXEP andUAconcentrations in thewide linear ranges from 0.3−300μM and 0.7−300 μMwith LOD of 0.09 μMand 0.4 μM, respectively. The CuFe2O4/1H3MBr/PE was suggested as an excellent platform for determination of DXEP and UA in real samples.