| Authors | Mostafa Shourian, Hedayatollah Ghourchian, Hossain Ali Rafiee Pour, Hassan Tavakoli |
|---|---|
| Journal | Journal of The Iranian Chemical Society |
| Page number | 900-907 |
| Serial number | 4 |
| Volume number | 7 |
| Paper Type | Full Paper |
| Published At | 2010 |
| Journal Grade | ISI |
| Journal Type | Typographic |
| Journal Country | Iran, Islamic Republic Of |
Abstract
In the presence of low energy gamma emitter radioisotopes of thallium-201 (201Tl) or technetium-99m (99mTc), H2O2 was
generated via radiolysis of water. The produced H2O2 was amperometrically determined using an anthraquinone 2-carboxylic acid
modified horseradish peroxidase on glassy carbon electrode. In the presence of each radioisotope, the cathodic current produced
due to the amperometric detection of H2O2, was designated as biosensor response. At the applied potential of -550 mV (vs.
Ag/AgCl), the biosensor showed the sensitivities of 1.937 and 2.278 nA h μGy-1 towards H2O2 produced by 201Tl and 99mTc
respectively. Finally, the calibration curves for dose rate determination of 201Tl and 99mTc have been presented and the correlations
between biosensor response to H2O2 and the gamma emitter dose rates for 201Tl and 99mTc are established.