Relative between PKD and Breast Cancer Invasion

چکیده مقاله

Introduction: Protein kinase D is a family of serine/threonine kinase superfamily. Three mammalian genes encode three different isoform of PKD. The different between them related to their domains, contains catalytic domain, binding domain C1 and pleckstrin homology domain. PKD play important role in many cellular processes, for example basic signaling mechanisms, stress oxidative, angiogenesis and recently demonstrate that directly negative effect on cell migration and invasion on tumor cells. Material and Methods: now a day abnormal expression of PKD is observe in many cancer cell, such as pancreatic, gastric, lymphoma, etc. In this review we focused on PKD changes in breast cancer. Results: in the highly invasive cell lines same as SKBR3, T47D observed little or no PKD1 express, while in very low invasive breast cancer cell lines such as MCF-7 and BT-474 moderate expression of PKD1 was observed. New study determined that low level of PKD1 expression in highly invasive lines related to epigenetic silencing by DNA methylation. Also suggest that role of PKD1 in cancerous cells may relate with matrix metalloproteinase (MMP), because PKD1 act as a negative regulator of MMP expression. Another critical function of PKD1 phosphorylation of SSH1L, so has a negative effect on cell migration. Conclusion: finally determined that decreased PKD expression can act as a marker in metastatic breast cancer. And since PKD suppress metastasis of breast cancer today regulate of PKD is one of the important goals in the treatment of breast cancer.