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Roohallah Nakhaei Sistani

Roohallah Nakhaei Sistani

Assistant Professor

College: Faculty of Chemistry

Department: Cell and Molecular Biology

Degree: Ph.D

Birth Year: 1979

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Roohallah Nakhaei Sistani

Assistant Professor Roohallah Nakhaei Sistani

College: Faculty of Chemistry - Department: Cell and Molecular Biology Degree: Ph.D | Birth Year: 1979 |

Assistant Professor

Molecular Genetics, University of Kashan, Kashan, Iran, 2013-Now

Field of interest: Biology of morphine addiction, miRNAs, Cancer biology, Herbal medicine, Bioinformatics. MicroRNAs are small RNA molecules which regulate many biological processes, including development, cancer, and also
addiction. And Bioinformatics, in my opinion, is a tool to explain many aspects of molecular biology, and unraveling neglected data, especially mass data. Iran has a great history of medicine based on herbs and working on herbs is promising for incurable diseases.

Ph.D

Molecular Genetics, Tarbiat Modares University, Tehran, Iran, 2008-2013.

During my Ph.D., I was working on microRNAs involving in morphine response in BE-2-C neuronal cell line as a model for molecular events happening in cells in the process of opioid addiction. Our data analysis indicates many biological pathways which could be involved in this process.

Master of Science

Molecular Genetics, Tarbiat Modares University, Tehran, Iran, 2002-2005.

Have you ever heard about DIAPOPS. This is a PCR-based technique which does not need for agarose gel electrophoresis. It uses a probe and enzymatic reaction for visualizing PCR products. I used this technique to detect fastidious adenoviruses in stool samples in my Ms.c.

Bachelor of Science

Plant Biology, Ferdowsi University, Mashhad, Iran, 1997-2002.

نمایش بیشتر

HLA-DQB1*06 May Predispose People to Multiple Sclerosis (MS)

Authorsنفیسه خلیلی,روح اله نخعی سیستانی,هادی شیرزاد
JournalBiomacromolecular Journal
Page number56
Volume number8
IFثبت نشده
Paper TypeFull Paper
Published At2024-05-08
Journal GradeScientific - research
Journal TypeElectronic
Journal CountryIran, Islamic Republic Of
Journal IndexISC

Abstract

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system that leads to the disability of the affected people. The etiology of the disease is not clear, but it is believed that it has an autoimmune nature. Several studies suggested that the major histocompatibility complex (MHC) class II loci are the most prominent genetic risk factor for MS susceptibility. The Human leukocyte antigen (HLA) DQB1*06 allele was introduced in numerous studies as the MS genetic predisposition factor, but there is a debate about it in different regions. Objective: This study aims to analyze the association of the HLA-DQB1*06 allele in Tehran. Method: Blood samples were collected from 117 MS and 114 healthy people. DNA was extracted, and genotyping was performed using allele-specific primers. Results: Our results showed that the HLA-DQB1*06 allele is significantly associated with MS (p-value < 0.000, odds ratio = 0.059, 95% CI = 0.02 to 0.14). The homozygous genotype was also more prevalent in the MS group compared with the control (p-value < 0.000, odds ratio = 0.2, 95% CI = 0.1-0.39). Our results show there is no difference in allelic distribution of this gene between men and women. Conclusion: Our data suggest that the HLA-DQB1*06 could be considered as an important genetic risk factor for MS in Tehran.