Synthesis of Thiazoles Catalyzed by Dichlorotriazine Attached to Graphene Oxide

Abstract

Among their valuable activities, 1,3-thiazoles show anticancer,1 antimicrobial,2 antiinflammatory, 3 and anti-Candida properties.4 These properties make 1,3-thiazoles appealing goals in organic synthesis. Past reports on the synthesis of 1,3-thiazole derivatives have mentioned such catalysts as DBU,5 HClO4-SiO2,6 Bi(SCH2COOH)3,7 [Et3NH][HSO4],8 and ytterbium(III) triflate.9 Each of these procedures may have its own advantages but also suffer from such apparent drawbacks as prolonged reaction times, complicated workup, low yield, or hazardous reaction conditions. Recently, graphene oxide (GO) has attracted significant interest as a catalyst in organic synthesis.10–11 Graphene and GO have large specific surface areas, chemical stability and high surface-to-volume ratios.12–13 GO is an efficient platform for functionalized graphene platelets that can potentially confer mechanical, thermal and electronic properties.