Rosa Damascena mediated ZnO-Red Ochre nanocomposite for the electrochemical determination of 5-Fluorouracil

چکیده مقاله

In this study, ZnO-Red Ochre nanocomposite was green synthesized by Rosa Damascena (RD) extract (RDZRONCs). Proton Induced X-ray Emission microanalysis (Micro-PIXE) and X-ray diffraction (XRD) pattern confirmed the presence of hematite (Fe2O3), and quartz (SiO2) mineral phases in the Red Ochre (RO) nanoclay. In addition, the XRD pattern shows the ZnO, ZnFe2O4, SiO2, Fe2O3, and Si phases in the RDZRONCs that were green synthesized with natural RD extract and RO. The RDZRONCs were used to modify the carbon paste electrode (CPE) for the electrochemical determination of the anticancer drug 5-fluorouracil (5-FU). Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques were employed to investigate the surface behavior of modified CPE (RDZRONCs/CPE). The electrochemical behavior of 5- FU at the RDZRONCs/CPE was exanimated by CV, differential pulse voltammetry (DPV), chronoamperometry (CA), and chronocoulometry (CC). Based on the DPV technique, a linear relationship between peak current and concentration of 5-FU was obtained in the dynamic range of 0.05–140.0 lM and with a detection limit equal to 0.0016 lM. The selectivity of RDZRONCs/CPE for 5-FU was studied in the presence of different inorganic and organic species. Also, the content of 5-FU was measured in real samples by RDZRONCs/CPE.