| Authors | F. Tavakkolib- M. Zahedifar-, E. Sadeghia |
|---|---|
| Journal | Photodiagnosis and Photodynamic Therapy |
| Paper Type | Full Paper |
| Published At | January 2018 |
| Journal Grade | ISI |
| Journal Type | Typographic |
| Journal Country | Iran, Islamic Republic Of |
Abstract
LaF3: Ag nanoparticles (NPs) were synthesized by the co-precipitation method. The produced NPs were characterized
by X-ray diffraction (XRD) pattern, scanning electron microscope (SEM), dynamic light scattering
(DLS) and Fourier transform infrared spectroscopy (FTIR). The emission spectrum of LaF3:Ag NPs is mostly
overlapped with the absorption band of protoporphyrin IX (PpIX) and their conjugation was confirmed by
studying fluorescence resonance energy transfer (FRET) from LaF3:Ag donor to protoporphyrin IX acceptor. The
energy transfers from LaF3:Ag NPs to photosensitizer molecules is very efficient. So, the produced LaF3:Ag NPs
can be recommended as light source for photodynamic therapy (PDT). The thiol group of cysteine was bound to
LaF3:Ag NPs in order to conjugate LaF3:Ag NPs and protoporphyrin IX. UVC light source was used to excite
fluorescent LaF3:Ag NPs. The reactive oxygen species (ROS) produced by photosensitizer was identified using
special fluorescent probes (anthracene, methylene blue and methyl orange) as detectors.