Alpha Amylase inhibitory plants

Abstract

Alpha-amylase is a low molecular weight endohydrolase enzyme that catalyzes the hydrolysis of starch and, ultimately, the production of glucose. This enzyme is considered one of the key enzymes and its inhibition can play a significant role in the treatment of diabetes. By controlling the catalytic activity of this enzyme, we can expect a reduction in glucose production in the post-meal phase, which can be a therapeutic advantage for people with diabetes. Today, the importance of using natural sources as inhibitors of alpha-amylase enzyme compared to chemical inhibitors has been much considered due to fewer side effects. Plant’s inhibitory effects on this enzyme can be attributed to their secondary metabolites, such as phenolics, terpenoids, flavonoids and coumarin phytochemicals. Some plant extracts, especially extracts rich in proanthocyanidin, can inhibit enzymes such as alpha-amylase, which can help control and treat diabetes.