| Authors | مهناز امیری ابراهیم اباد,مسعود صلواتی,پرداختی عباس,میثم احمدی,احمد اکبری |
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| Journal | MAT SCI ENG C-MATER |
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| IF | 4.164 |
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| Paper Type | Full Paper |
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| Published At | 0000-00-11 |
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| Journal Grade | Scientific - research |
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| Journal Type | Electronic |
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| Journal Country | Iran, Islamic Republic Of |
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| Journal Index | ISI |
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Abstract
Hydrogel beads are promising delivery systems for encapsulation and release of drugs due to the mild process of
their fabrication from biopolymers. Magnetic CoFe2O4 nanoparticles (MCFO, 9.72 nm in diameter) were
synthesized via a co-precipitation method using caffeine as a new environmentally friendly material in order to
alkalinize the medium. Drug-targeting Magnetic beads based on CoFe2O4 nanoparticles, sodium alginate and
chlorpheniramine maleate (CPAM) were synthesized in the presence of Ca2+ ions to obtain ionic cross-linked
magnetic hydrogel beads. Nanoparticles as well as produced magnetic beads were thoroughly characterized by
FTIR, XRD, SEM, nanosizer and VSM techniques. The swelling ratio of beads indicated pH-dependent property
with maximum water absorbing at pH 7.4. The in vitro release of beads exhibited significant behavior on the
subject of nanoparticles concentration and alginate content. Biocompatibility of the CFO nanoparticles and
MCFO/Alg beads are demonstrated through cytotoxicity test via MTT ssaay on U87 cell lines.
