Synthesis and in vitro evaluation of a novel magnetic drug delivery system; proecological method for the preparation of CoFe2O4 nanostructures

Abstract

Magnetic iron oxide nanoparticles have been extensively utilized in a wide range of biomedical applications, in order to improve the efficiency of themagnetic nanoparticles in therapeutic applications,we report here, the synthesis of magnetic CoFe2O4 nanoparticles. Since CoFe2O4 nanoparticles exhibit high application potential, developing new and environment-friendly methods for its preparation has become extremely useful. Based on the ethics of “Green Chemistry”, newmaterial for obtaining nanoparticles by co-precipitationmethod have been developed. Glycyrrhizaglabra, an herbalmedicinewhose physicochemical properties allows it to be used as a base to alkalinize media and as a reducing agent to prepare stable nanostructures, was used towards the principles of green and sustainable production. In this study, an intelligent drug delivery system was developed by capping chlorpheniraminemaleat and magnetic cobalt ferrite nanostructures in calcium alginate beads. The versatile beads could exploit the merits of controlled release of the drug by application of an alternating magnetic field. The magnetic nanoparticles as field-controlled drug carriers offer a unique power of magnetic guidance and field-triggered drug release behavior. Biocompatibility of the nanoparticles and beads are demonstrated through cytotoxicity test on A 172 cell line that indicated no cytotoxic effect after 24 and 48 h. Thankfulness to the natural origin of base substance, the applied process may be described as eco-friendly.