A comparative screening of the catalytic activity of nanocrystalline MIIZr۴(PO۴)۶ ceramics in the one-pot synthesis of ۱,۶-diamino-۴-aryl-۲-oxo-۱,۲- dihydropyridine-۳,۵-dicarbonitrile derivatives

چکیده مقاله

A four-component reaction of hydrazine hydrate, ethyl cyanoacetate, malononitrile, and aromatic aldehydes was achieved in the presence of nanocrystalline MIIZr4(PO4)6 ceramics (MII: Mn, Fe, Co, Ni, Cu, Zn, Cd) as heterogeneous catalysts to produce N-amino-2-pyridones. The reactions were performed in the presence of different catalysts, and it is observed that CdZr4(PO4)6 nanocrystallines are the best catalysts among those examined. Atom economy, excellent yields in short times, high catalytic activity, recycling of catalyst, and environmental benignity are some of the important features of this protocol.