Investigation the relationship between ER and PR prognostic factors with stage of disease in breast cancer

چکیده مقاله

Introduction: Breast cancer is the most common malignancy and the second leading cause of cancer death in women. The growth of breast cancer often is regulated by women steroid hormones. Estrogen receptors (ER) and progesterone receptors (PR) are the member of nuclear steroid hormone receptor family. These receptors use as an important indicator for hormone therapy in breast cancer. Patients who are positive for estrogen and progesterone receptors respond to hormone therapy and those who are not, will be treated by other treatments such as chemotherapy. Methods: In this study, the information contained in the records of 56 patients with breast cancer who referred to Shahid Beheshti University of Medical Sciences Research Center breast cancer or Tehran Azar clinic (from 1388to 1392) was evaluated. Collected data was analyzed by using of SPSS software and multi-dimensional chi- square test. Results: The results showed that breast tumors in 12.5% of patients were in stage I, in 48.2% of patients were in stage II, in 35.5% of patients were in stage III and 1.8% of patients were in stage IV.The frequency of ER in breast tumor stages I, II, III and IV is 57.14%, 85.19%, 52.38% and 1.8% respectively. The results showed that the frequency of the progesterone hormone receptors PR in breast tumor stages I, II, III and IV were respectively 42.85%, 77.77%, 42.86% and 0%. The results showed that estrogen and progesterone receptors have highest frequency in stage II of disease. Conclusion: In this study there isn’ t any relationship between stage and existence of estrogen receptors (Χ2 =6.998, df= 3, exact= 0.055). In addition, with 95% confidence interval there was a significant relationship between exposure of disease at different stages and progesterone receptor (Χ2 = 8.386, df= 3, exact= 0.025)