Comparative investigation of ۲-methylanthraquinone with doxorubicin in interaction with DNA

چکیده مقاله

The study on the interaction of small molecules with DNA has great significance and implications in several biological applications such as cancer chemotherapy [1]. Many anticancer drugs in clinical use like anthracyclines (Doxorubicin and Daunomucin) interact with DNA through intercalation and inhibit DNA synthesis thus preventing the replication of rapidly growing cancer cells [2, 3]. It seems that anthraquinone compounds with structural similarity to Doxorubicin can interact with DNA and intercalate between base pairs of DNA. In the present study 2-methylanthraquinone is analyzed for its possible interaction with chicken liver DNA in Tris-HCl buffer (pH=7.4) by UV-Vis spectrophotometry and its interaction was compaired with Doxorubicin. The results of experiments showed that interaction of Doxorubicin with DNA is more effective than 2-methylanthraquinone and the interaction rate depends on concentration of intercalator compounds.