Green Synthesis of MnO2 Nanoparticles Using Cumin Extract Composited with Hypericum Plant: Investigation of Antibacterial and Anticancer Properties

چکیده مقاله

Cancer is a major cause of morbidity and mortality. Although there are many treatment techniques, these methods still have many limitations. Nanotechnology is rapidly growing and flourishing in the field of diagnosis and treatment of various diseases. The antibacterial and anticancer properties of nanoparticles (NPs) have made them promising for the treatment of diseases. In this study, manganese dioxide (MnO2) NPs are green-synthesized by the cumin extract as a regenerator and stabilizer in a co-precipitation method. The synthesized NPs are then composited with the Hypercom perforatum plant. In order to characterize the structure and morphology of MnO2 NPs, XRD, FTIR, SEM, and TEM analyses are performed. MnO2 NPs composited with the Hypericum plant were tested for their antibacterial efficacy against strains of Staphylococcus aureus and Pseudomonas aeruginosa. The MTT cytotoxicity assay was used to assess the anticancer effects of MnO2 NPs composited with the Hypericum plant. In this instance, it was looked into how the NPs affected the human Hela cervical cancer cell line and the cancerous fibroblast cells. Based on these results, MnO2 NPs can damage Hela cells without damaging healthy cells. This investigation can provide fundamental insights for understanding the antibacterial activity and cytotoxicity of these NPs and point out their applicability for use in the biomedical field.