Electrocatalytic oxidation of antihypertensive drug on a copper hydroxide nanoparticles modified electrode

چکیده مقاله

Electrochemical sensors and biosensors for pharmaceutical, food, agricultural and environmental analyses have been growing rapidly due to electrochemical behavior of drugs and biomolecules and partly due to advances in electrochemical measuring systems. Methyldopa is an antihypertensive agent that is used in the treatment of high blood pressure or hypertension, especially when it is complicated with renal disease [1]. Its antihypertensive properties are primarily due to its action on the central nervous system. Methyldopa inhibits the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine, and is a precursor for norepinephrine and subsequently epinephrine. It is converted to α-methyl norepinephrine in adrenergic nerve terminals, and its antihypertensive action appears to be due to its stimulation of central adrenal receptors, which reduces sympathetic tone and produces a fall in blood pressure [2]. Clearly, detection and quantification of methyldopa is an important feature in pharmaceutical and clinical procedures. In the present work, we describe the preparation of a new electrode composed of carbon paste electrode modified with Cu(OH)2 nanoparticles and investigate its performance for the electrocatalytic determination of methyldopa in aqueous solutions.