Synthesis of bis-spiro-substituted piperidines using nano-CuFe2O4@Chitosan under ultrasonic conditions

چکیده مقاله

An efficient pseudo six-component synthesis of 15-(aryl)-3,3,11,11-tetramethyl-15-azadispiro[5.1.5.3]hexadecane-1,5,9,13-tetrone is described by one-pot condensation of formaldehyde, dimedone, and aromatic amine using nano-CuFe2O4@Chitosan under ultrasonic conditions. The catalyst was characterized by XRD and scanning electron microscopy (SEM). Use of simple and readily available starting materials, experimental simplicity, applying the sonochemical methodology as an efficient method and innocuous means of activation in synthetic chemistry are some advantages of this protocol.