An efficient synthesis of 2,2-(Phenylmethylene)bis(5,5- dimethylcyclohexan- 1,3-dion) derivatives using ZnS nanoparticle

چکیده مقاله

A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported.1 The reactions between dimedone and a variety of aldehydes were carried out using zns nanoparticls in water to afford tetraketones. They are organic multifunctional molecules with four carbonyl groups. Tetraketones have exhibited important biological activities such as tyrosinase inhibition, lipoxygenase inhibition and antioxidant activities. In modern organic chemistry, the improvement of reaction efficiency, the avoidance of toxic reagents, the reduction of waste, and the responsible utilization of our resources have become critical intentions. By keeping these ideas in mind, a simple and green approach for the synthesis of tetraketones has been developed.2 Among all the reactions were performed in the presence of different catalysts, it is observed that ZnS nanoparticles are the best catalysts.3 Zinc-based nanoparticles have great potential to be used as a catalysts for a variety of organic and inorganic reactions due to their high surface-to-volume ratio (