Synthesis of ۱,۶-diamino-۳,۵-diethynyl-۴-phenylpyridin-۲(۱H)-one derivatives via a one-pot four-component reaction by using CoS nanoparticle

چکیده مقاله

A four-component reaction of hydrazine hydrate, ethyl cyanoacetate, malononitrile, and aromatic aldehydes was achieved in the presence of nanoparticle CoS as heterogeneous catalysts to produce N-amino-2-pyridones. Pyridones exhibit important biological properties such as antibacterial, antifungal, antitumor, and potential HIC-1 specific transcriptase inhibitors. Therefore the synthesis of 2-pyridones has been reported using K2CO3/H2O under microwave irradiation, bipyridinium chlorochromate (BPCC), magnesium oxide (MgO) and bismuth(III) nitrate pentahydrate (Bi(NO3)3 5H2O), piperidine, and Et3N, trifluoroacetic acid (TFA), [bmim]BF4. However, some of the reported methods have disadvantages including long reaction times, harsh reaction conditions, and use of toxic and non-reusable catalysts.