CoAl۲O۴ spinel nanocrystals as a novel catalyst for synthesis of ۲,۳- dihydroquinazolin-۴(۱H)-ones

چکیده مقاله

As one of the most frequently encountered heterocycles in medicinal chemistry, quinazolinones are present in a large family of products with broad pharmacological properties including antitumor, antibacterial, anticonvulsant, and anti-inflammatory.1 Because of their wide range of biological applications, the synthesis of these compounds have received a great deal of attention. The most common synthetic methods reported for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives involve the cyclocondensation reaction of isatoic anhydride with a primary amine and aldehydes catalyzed by p-TsOH,2 AcOH,3 [bmim]HSO4,4 KAl2(SO4)2.5 However, many of these synthetic methodologies are associated with several limitations.